J. Tummatorn, Piyapratch Poonsilp, Phongprapan Nimnual
Apr 22, 2015
Citations
0
Influential Citations
32
Citations
Journal
The Journal of organic chemistry
Abstract
Regioselective synthesis of 3-bromoquinoline derivatives was achieved via a formal [4 + 2]-cycloaddition between N-aryliminium ion, generated from arylmethyl azides, and 1-bromoalkynes. This method could also be applied to other quinoline derivatives using appropriate alkynes. Moreover, the current strategy could be utilized for the diastereoselective synthesis of tetrahydroquinoline derivatives employing alkenyl substrates in good to excellent yields.