S. Bagul, J. Rajput, R. Bendre
Jun 6, 2017
Citations
1
Influential Citations
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Journal
Environmental Chemistry Letters
Abstract
The 3-carboxycoumarin is a major heterocycle in many biologically active agents, including anti-cancer, antibacterial and cosmetics. 3-Carboxycoumarins are also involved in the actions of plant growth hormones and growth regulators. Many catalytic systems have been used for the synthesis of 3-carboxycoumarins but such systems present issues such as harsh reaction conditions, tedious work-up and use of toxic solvents. Therefore, here we tested the synthesis of 3-carboxycoumarins by one-pot Knoevenagel condensation and intramolecular cyclization of various 2-hydroxybenzaldehydes with meldrum’s acid, using water extract of banana. Products were obtained in 76–94% yields in 420–490 min at room temperature by simple filtration.