Zhang Qingwen
2011
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Journal
The Chinese Journal of Modern Applied Pharmacy
Abstract
OBJECTIVE To develop a practical process for 3-chloro-4-(3-fluorobenzyloxy)aniline.METHODS 3-Chloro-4-(3-fluorobenzyloxy)aniline was synthesized from 1-(chloromethyl)-3-fluorobenzene and 2-chloro-4-nitrophenol via condensation in the presence of potassium carbonate,followed by reduction with Fe/NH4Cl.RESULTS The overall yield of this process was 82%.The target product was characterized by TLC,melting point and 1H-NMR.CONCLUSION This synthetic process features are cheap and readily available starting materials,robustness,less waste burden,thus should be amenable to industrial production.