Liu Xian-hua
2010
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Journal
Qilu Pharmaceutical Affairs
Abstract
OBJECTIVE To synthesis 3-cyclobutylpropanoic acid.METHODS 3-cyclobutylpropanoic acid was synthesized by the materials bromomethyl cyclobutane and diethyl malonate by condensation and decarboxylation.RESULTS 3-cyclobutylpropanoic acid was synthesized and the total yield of the target compound was 83%.CONCLUSION The synthetic procedure was concise the reaction steps were less,the procedure was suitable for industrial production.