D. Guiadeen, S. Kothandaraman, Lihu Yang
Oct 27, 2008
Citations
0
Influential Citations
10
Citations
Journal
Tetrahedron Letters
Abstract
Abstract An expeditious and concise synthesis of 3-(difluoromethoxy)-5,6,7,8-tetrahydro-1,6-naphthyridine and 3-(trifluoromethoxy)-5,6,7,8-tetrahydro-1,6-naphthyridines is described. Starting from N -benzyl piperidone, the key intermediates leading to these two biologically desirable synthones were rapidly assembled by inverse electron demand Diels–Alder (IEDA) reaction utilizing microwave irradiation. The scope of the microwave methodology developed herein was extended to other ketones.