Sang J. Chung, D. H. Kim
Nov 13, 1995
Citations
0
Influential Citations
14
Citations
Journal
Tetrahedron
Abstract
Abstract A general synthetic method for the preparation of 5,12-dihydro-5-oxobenzoxazolo[3,2-a]quinoline-6-carboxylic acids has been developed making use of the tandem double ring closure reaction of N-(2-hydroxyphenyl)anthranilic acid as the key step. 2-(4-Methylpiperazin-1-yl)-3-fluoro-5,12-dihydro-5-oxobenzoxazolo[3,2-a]quinoline-6-carboxylic acid, an oxygen isostere of a potent antibacterial, A-57,207 was thus synthesized.