Wang Bao-jie
2006
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Journal
Journal of Shenyang Pharmaceutical University
Abstract
Objective To prepare compound 3-fluoro-4-methoxybenzaldehyde and simplify the synthetic method.Methods 3-Fluoro-4-methoxybenzaldehyde was prepared through the reaction of 2-fluoroanisole with hexamethylenetetramine in the presence of trifluoroacetic acid,and then extracted with anhydrous ether from the mixture after basification with potassium carbonate.Results 3-Fluoro-4-methoxybenzaldehyde was obtained successfully.Its structure was identified by melting point and()~1H-NMR analysis.The yield was up to 87.3%.Conclusions The reported two-step synthetic method of 3-fluoro-4-methoxybenzaldehyde has been simplified into one step.In addition,the damage that produced by lots of concentrated hydrochloric acid and sulfuric acid to the industrial production has been avoided.Trifluoroacetic acid can be recycled,which greatly reduced the cost.