Lu Zhou
2008
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0
Influential Citations
1
Citations
Journal
Fine chemicals
Abstract
3-Fluoro-4-nitrophenol(FNP),an important fluoric intermediate,was synthesized from m-fluoroaniline by a four-step way including diazotization,hydrolysis,nitration and separation of the isomers.The diazonium salt of m-fluoroaniline was hydrolyzed by the technology of reaction distillation in the solution of CuSO4 and H2SO4 to give m-fluorophenol in 85% yield and of 95% purity.After nitration of m-fluorophenol,steam distillation was used to remove the by-product 3-fluoro-6-nitrophenol,then the residual bottom liquid was extracted with Et2O.The Et2O layer was washed with saturated aqueous NaCl and NaHCO3,and poured to a solution of Na2CO3.The precipitated sodium salt of FNP was dissolved in water,acidified,extracted by Et2O and evaporated to give FNP in 23% yield and of 99.6% purity.