M. Hudlický
Aug 1, 1988
Citations
0
Influential Citations
9
Citations
Journal
Journal of Fluorine Chemistry
Abstract
Abstract A new synthesis of 3-fluoroaspartic acid is based on the reaction of dibenzyl difluoromaleate (3) with dibenzylamine. Reduction of this product (4) with sodium cyanoborohydride gave dibenzyl 2-dibenzylamino-3-fluorosuccinate (5), and thence hydrogenolysis of the benzyl groups afforded fluoroaspartic acid (6). Stereochemistry of the products and of the intermediates is discussed.