Dian‐Zhao Lin, Jing‐Mei Huang
Jul 16, 2019
Citations
0
Influential Citations
23
Citations
Journal
Organic letters
Abstract
A new method for 3-formalytion of indoles has been developed through electrochemical decarboxylation of glyoxylic acid with the amine as a dual function organocatalyst. The amine facilitated both the electrochemical decarboxylation and the nucleophilic reaction efficiently, whose loading can be as low as 1 mol %. This protocol has a broad range of functional group tolerance under ambient conditions. The gram-scale experiment has shown great potential in the synthetic application of this strategy.