H. Buchstaller, K. Wilkinson, K. Burek
Oct 1, 2011
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Influential Citations
11
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Journal
Synthesis
Abstract
A straightforward and effective procedure for the prepa- ration of 1H-indazole-3-carboxylic acid esters and amides was de- veloped. A series of functionalized 3-iodoindazoles were subjected to Pd-catalyzed carbonylations in the presence of methanol or amines, yielding the title compounds in moderate to good yield. For the majority of examples, the reaction proceeded cleanly under mild conditions, which were readily tolerated by a diverse range of func- tional groups that allow further synthetic transformations.