Cheng Chuan
2011
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Journal
Journal of University of South China
Abstract
3-methyl-5-phenyl-(2-difluorophenyl)-2-morpholinol Hydrochloride was synthesized from 1-(2-difluorophenyl)-2-bromo-1-Acetone and Phenylglycinol in polar solvents NMP by amine,cyclization reaction,reduction and acidification.The yield amounted to 70.3%.The structures of the target compounds were confirmed by means of IR,1H NMR and MS spectra.This new compound has never been reported at home and abroad.The synthesis method in the article has advantages of shortening reaction time,mild conditions and high yield.