J. Marco-Contelles
Dec 5, 2022
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Quality indicators
Journal
Synthesis
Abstract
Herein it is summarized and critically discussed the different methods reported in the current literature and patents for the synthesis of 3-nitrooxypropanol (3-NOP). Among the small molecules 3-NOP is possibly one of the smallest (Chemical Formula: C3H7NO4; Molecular Weight: 121,09) showing interesting biological properties. Particularly, 3-NOP is an efficient inhibitor of methyl CoM reductase, an enzyme that catalyzes the last step of methanogenesis in anaerobic systems (e.g. ruminants), and a potent methane mitigant, able to reduce greenhouse gas emissions and climate change. 3-NOP is the active ingredient of Bovaer,® a feed additive for all sort of ruminants. Furthermore, 3-NOP has been incoporated in a number of nitrate esters as NO-donors, showing diverse pharmacological activities for the treatment of inflammation, or cardiovascular diseases