Peng Youlin
2011
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0
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Journal
Chinese Journal of Pharmaceuticals
Abstract
3-(S)-(1-Carbamoyl-1,1-diphenylmethyl)pyrrolidine,an intermediate of derifenacin hydrobromide,was synthesized from trans-4-hydroxy-L-proline by decarboxylation,N-Boc protection and chlorination to give N-Boc-3-(S)-chloropyrrolidine,which was subjected to condensation with diphenylacetonitrile in presence of potassium t-butoxide,hydrolysis,deprotection,treatment with L-(+)-tartaric acid and then alkalization.The overall yield was about 14%.