Y. Tsuzuki, K. Chiba, Kazuhiro Mizuno
Nov 26, 2001
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Influential Citations
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Journal
Tetrahedron-asymmetry
Abstract
Abstract Three synthetic methods for the preparation of (3S,4S)-3-methoxy-4-methylaminopyrrolidine, an important intermediate in the synthesis of the novel quinolone antitumor agent, AG-7352, have been developed. By one route, an efficient and large-scale preparation of the chiral pyrrolidine could be achieved through resolution of (±)-1-Boc-3-benzylamino-4-hydroxypyrrolidine, which is prepared from either 3-pyrroline or 1,4-dichloro-2-butene.