Lanting Xu, Yongwen Jiang, D. Ma
Feb 7, 2012
Citations
1
Influential Citations
137
Citations
Quality indicators
Journal
Organic letters
Abstract
CuI/4-hydroxy-L-proline catalyzed coupling of N-substituted o-bromobenzamides with formamide takes place at 80 °C, affording 3-substituted quinazolinones directly. Under these conditions other amides that were tested only provided simple coupling products, which can be converted into 2,3-disubstituted quinazolinones via HMDS/ZnCl(2) mediated condensative cyclization.