J. U. Jeong, Xiaohong Chen, Attiq Rahman
Feb 24, 2004
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23
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Journal
Organic letters
Abstract
[reaction: see text] A novel and practical synthesis of 3-substituted 3H-pyrimidin-4-ones is described. The key step involves the cyclization of enamide esters, derived from readily available beta-keto esters, with trimethylaluminum and various primary amines.