Hiroyuki Nakazumi, Tamio Ueyama, Hikaru Sonoda
1984
Citations
0
Influential Citations
20
Citations
Journal
Bulletin of the Chemical Society of Japan
Abstract
Reaction of 2-phenyl-4H-1-benzothiopyran-4-ones and related compounds with chloromethyl methyl ether and fuming sulfuric acid gave mainly 3-chloromethyl compound, whereas chloromethylation of methoxy-substituted thioflavones took place at another position or gave tris(chloromethyl) compound. 3-(Chloromethyl)thioflavone could be easily converted into various 3-(substituted methyl)thioflavones which showed significant antimicrobial activity against Trichophytons.