K. Murthy, A. Rey, M. Tjepkema
Jul 7, 2003
Citations
0
Influential Citations
22
Citations
Journal
ChemInform
Abstract
Abstract The asymmetric conjugate addition reaction between 4-fluorophenylmagnesium bromide and various chiral α,β-unsaturated esters and enoylsultam substrates was explored to prepare a key intermediate useful in the preparation of paroxetine. The most selective auxiliary was found to be Oppolzer's (1S)-(−)-camphorsultam. Interestingly, the diastereoselection was opposite to that reported for acyclic enoylsultams.