Yi You, Yueji Chen, Chenhui You
Oct 30, 2019
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Influential Citations
6
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Journal
Organic & biomolecular chemistry
Abstract
An efficient method for the synthesis of structurally diverse 4-aryl-3-(tri/difluoromethyl)-1H-1,2,4-triazol-5(4H)-ones through the cyclization of hydrazinecarboxamides with tri/difluoroacetic anhydride is presented. The method is simple and environmentally benign, providing tri/difluoromethylated 1,2,4-triazol-5(4H)-ones in moderate-to-good yields. A mechanism is proposed to proceed via a tandem reaction of tri/difluoroacetylation, nucleophilic addition and water elimination. Some of these compounds exhibit promising insecticidal activities.