A. Kagemoto, M. Kishi, Y. Minaki
Jul 1, 1973
Citations
0
Influential Citations
3
Citations
Journal
Journal of Labelled Compounds and Radiopharmaceuticals
Abstract
A simple procedure to synthesize 1, 4-bis (3′-bromopropionyl) piperazine-2, 3-14C, pipobroman-14C(I-14C), via piperazine-2, 3-14C (V-14C) was described. The condensation of 1, 2-bis(bensy lamino) ethane(II) with ethylene dibromide-1, 2-14C gave 1, 4-dibensylpiperazine-2, 3-14C(III-14C) in 34% yield. III-14C was catalytically reduced in glacial acetic acid on Pd-C to afford piperazine-2, 3-14C diacetate (IV-14C) in 90% yield, followed by the conversion in aqueous solution to free V-14C which was in turn subjected to a Schotten-Bauman reaction with 3-bromopropionyl chloride to give I-14C in 69% yield.