Zeng Yan-xia
2009
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Journal
Journal of Huaqiao University
Abstract
Synthesis method of 4-[1,2,4] triazol-1-ylmethyl-benzonitrile was improved by using the cheaper 4-(chloromethyl) ben-zonitrile instead of 4-(bromomethyl) ben-zonitrile as the raw material.Reaction conditions for the preparation of 4-[1,2,4] triazol-1-ylmethyl-benzonitrile from 4-(chloromethyl) ben-zonitrile and 1H- triazole by N-hydrocarbylation were investigated.The experimental results indicated that the optimal reaction conditions are as follow: 4-(chloromethyl) ben-zonitrile 0.03 mol,1H-[1,2,4] triazole 0.045 mol,acetonitrile solvent 20 mL,the mixed base(anhydrous K2CO3∶KOH=1∶1) 0.03 mol,temperature 70 ℃ and reaction time 5 h;under this reaction condition,the yield of the objective compound can reach 76%.