Wang Shuang-shou
2008
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Journal
Chinese Journal of New Drugs
Abstract
Objective:To synthesize 4-(2',4'-difluorophenyl) acetophenone by cross-coupling.Methods: Using THF/H2O as the solvent,4-(2',4'-difluorophenyl) acetophenone was synthesized from 2',4'-difluorophenylboronic acid and 4-bromoacetophenone via cross-coupling mediated by the Pd(II) complex.Results and Conclusion: When a mixture of aqueous and organic solvents was reacted at room temperature,a high catalytic activity for preparing 4-(2',4'-difluorophenyl) acetophenone and 93% yields were obtained.This synthesis provides a practical procedure for industrial applications.