Yin Dulin
2007
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Journal
Fine Chemical Intermediates
Abstract
Novel compound 4-(2-ethoxy-2-oxo-ethoxy)-3-nitrobenzoic methyl ester(3)was prepared from 4-hydroxy-3-nitrobenzoic methyl ester(1) and 2-bromoacetic ethyl ester(2). Through investigation of effec of reacting conditions on yield the optimum process conditions were determined as following: reaction temperature is 50℃,time 4 h and n(1) ∶ n(2) ∶ n(K2CO3)=1 ∶ 1.2 ∶ 1.5. The yield and the purity was 96.9% and 98.9%. The structure of 3 was confirmed by elementary analysis,IR,and 1H NMR.