Yuan Guo-qing
2013
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Journal
Chemistry World
Abstract
4-(3-Amino-2-carboxy phenyl) butanoic acid is the key intermediate for the synthesis of new thymidylate syntheses inhibitors.The target compound was synthesized from 3-(3-nitro benzoyl) propionate ether via nitro reduction,carbonyl reduction,cyclization,and ring-opening reactions.This method has the advantages of low cost and mild reaction conditions,and it is suitable for production in industrial scale.