Zeng Chu-yi
2003
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Journal
Fine chemicals
Abstract
Using o-aminobenzoic acid and formamide as raw materials,4(3H)-quinazolinone was synthesized without solvent under microwave irradiation and normal pressure.The results showed that the optimal reaction conditions were that,the mole ratio of formamide to o-aminobenzoic acid was 10,and microwave irradiation time was 8 min with the power of 180 W;before the reaction all o-aminobenzoic acid and a quarter of total mass of formamide were mixed at 60 ℃,then the remainder of formamide was added intermittently during the reaction.The conversation of o-aminobenzoic acid reached 96% and the total yield of 4(3H)-quinazolinone was above 94%.The reaction rate was increased by 45 times against ordinary heating.