W. Ye
2007
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Journal
Fine Chemical Intermediates
Abstract
4-(4-Chlorophenyl)cyclohexanol was synthesized from chlorobenzene,cyclohexene and acetyl chloride via Friedel-Crafts reation,Baeyer-Villiger reaction ,hydrolysis. By experiments utilizing an orthogonal design,optimum synthesis conditions of Friedel-Crafts reation and Baeyer-Villiger reaction were obtained. The total yield of 4-(4-chlorophenyl)cyclohexanol is 12.9%,which is 6% higher than the literature. 4-(4-chlorophenyl)cyclohexanol was oxidated with NaClO to give 4-(4-chlorophenyl)cyclohexanone with yield of 87%. This is a new synthesis route for 4-(4-chlorophenyl)cyclohexanone. The products were identified by 1H NMR,GC-MS.