Xu Li-li
2008
Citations
0
Influential Citations
0
Citations
Journal
Chemistry World
Abstract
4,4-Dimethoxy-2-butanone was synthesized through three-step process using sodium and methanol as the starting material.Firstly,the methanol solution of sodium methoxide was prepared.Secondly,a mixture of acetone and methyl formate was added into the methanol solution of sodium methoxide to prepare sodium formyl acetone by Claisen reaction.Lastly,4,4-dimethoxy-2-butanone was prepared through acetylizing reaction in methanol solution with sulfuric acid.The overall yield reached(73.1%) and the purity of the the product was 98.7%.The product was confirmed by IR and MS.Meanwhile,the effect of ratio of materials,temperature,reaction time,feeding speed and pH value on the reaction was investigated,and the optimum reaction conditions were obtained.