Yang Gui-qiu, Yu Chun-rui
2004
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Journal
Fine chemicals
Abstract
3-Chloro-N-hydroxy-2,2-dimethylpropanamide(Ⅳ) was prepared by reaction of chloro-pivalyl chloride(Ⅱ) with hydroxylamine hydrochloride(Ⅲ).By decreasing the reaction temperature to inhibit decomposition of Ⅱ and Ⅲ,the yield of Ⅳ was 91.4%.Then Ⅳ reacted with sodium hydroxide for 4~5 h to form 4,4-dimethyl-3-isoxazolidinone(Ⅰ) in 92.5% yield.The overall yield was over 84%.The cheap alkali liquor〔w(NaOH)=30%〕was used in both reactions.Structure of the product was identified by ~1HNMR,IR and MS spectra.