V. Dal Piaz*, G. Ciciani, M. Giovannoni
Mar 1, 1997
Citations
0
Influential Citations
9
Citations
Quality indicators
Journal
Farmaco
Abstract
A series of 4,5-functionalized-2-methyl-6-(substituted phenyl)-3 (2H)-pyridazinones were synthesized and evaluated as platelet aggregation inhibitors in human platelet rich plasma (PRP). The new products generally displayed significant higher activity with respect to the corresponding unsubstituted aryl compounds. Compounds 27 and 31 appeared of particular interest, being their IC50s in the submicromolar range. Structure-activity relationships (SARs) are discussed.