Defeng Xu, Zhiling Zhu, Ziqi Wang
Dec 1, 2013
Citations
0
Influential Citations
3
Citations
Journal
Journal of Chemical Research
Abstract
A convenient and efficient three-step synthesis of 4,6-dimethyl-2-(methylsulfonyl) pyrimidine can be achieved by cyclocondensation of acetylacetone and thiourea in the presence of hydrochloric acid to yield 4,6-dimethyl-1-merc aptopyrimidine, methylation with dimethyl carbonate and tetrabutylammonium bromide to give 4,6-dimethyl-2-methyl thiopyrimidine, and oxidation with hydrogen peroxide, sodium tungstate and tetrabutylammonium bromide to afford the title compound in an overall yield of 75%.