M. M. Martínez, Cristina Pérez-Caaveiro, Miguel Peña-López
Nov 1, 2012
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Influential Citations
8
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Journal
Organic & biomolecular chemistry
Abstract
4,6-Disubstituted-2-(4-morpholinyl)pyrimidines, an important class of bioactive compounds, have been synthesized from 4,6-dichloro-2-(4-morpholinyl)pyrimidine by selective and sequential palladium-catalyzed cross-coupling reactions using triorganoindium reagents. This methodology, being efficient and versatile, allowed the synthesis of a variety of non-symmetrical pyrimidines functionalized at C-4 and C-6 positions.