E. Aydemir, S. Kaban
2018
Citations
0
Influential Citations
3
Citations
Journal
Asian Journal of Chemistry
Abstract
Heterocyclic compounds and their derivatives are widely used in many fields of industry for the preparation of analytical reagents, ligands, dyestuffs, bioindicators and pharmaceutical substances. Such compounds are biochemically important compounds, which are tested as potential anticancer reagents and as active substances against HIV virus, in in vitro researches carried out as a result of the recent advances in chemotherapy. In addition, the importance of formazans increases constantly owing to their ability to form hydrogen bonds and their conjugated nitrous systems [1-4]. This study, which is aimed at contributing to the class of compounds as well as synthesizing new products that may be useful for both industrial and medical applications, consists mainly of two parts. In the first part of the study, 2,4,7-trimethylquinoline was prepared via ring-forming reaction from 4-(m-tolylamino)-3pentgne-2-on obtained from pentene-2,4-dione and m-toluidine by Combes synthesis. Oxidation of this heterocyclic compound with selenium dioxide, which is a selective oxidant gave 4,7dimethylquinoline-2-carboxaldehyde (I), which will be used as a substrate in present reactions. Synthesis of 4,7-Dimethylquinoline-2-carboxaldehyde by Condensation Reactions and Formation of Some New 3-Hetarylformazans