Ondrej Šimo, A. Rybár, J. Alföldi
1998
Citations
0
Influential Citations
4
Citations
Journal
Collection of Czechoslovak Chemical Communications
Abstract
New 4-alkyl- or 4-phenyl-7-methyl-1,2-dihydro-7 H -imidazo[1,2,3- cd ]purine-6,8-diones 1 were obtained by intramolecular alkylation of 8-alkyl- or 8-phenyl-9-(2-mesyloxyethyl)-1-methyl-9 H -purine-2,6(1 H ,3 H )-diones 5 . The necessary compounds 5 were prepared from 6-[(2-hydroxyethyl)- amino]-3-methyl-5-nitrosopyrimidine-2,4(1 H ,3 H )-dione ( 2 ), which was hydrogenated to 5-amino-6-[(2-hydroxyethyl)amino]-3-methyl derivative 3 ; consecutive reactions of the latter with an orthocarboxylate and mesyl chloride afforded 8-alkyl- or 8-phenyl-9-(2-hydroxyethyl)-1-methyl-9 H -purine- 2,6(1 H ,3 H )-diones 4 and compounds 5 , respectively.