Xu Nan-ping
2006
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Journal
Journal of Nanjing University of Technology
Abstract
Acetyl-pyridine is an important precursor for the synthesis of Schiff-Base ligands.4-hydroxyl-2,6-dicarbethoxypyridine was synthesized from chelidamic acid through the esterification reaction.The compound reacted with allyl bromide to give 4-allyloxy-2,6-dicarbethoxypyridine.Catalyzed by EtONa,The product reacted with ethyl acetate through the Claisen condensation.When the molar ratio of EtONa to 4-allyloxy-2,6-dicarbethoxypyridine was approximately 0.9∶1,only 4-allyloxy-6-acetyl-2-carbethoxypyridine was obtained.When the molar ratio was 5∶1,the final obtained product was only 4-allyloxy-2,6-diacetylpyridine.To the best of our knowledge,it is for the first time reported that the synthesis of 4-allyloxy-6-acetyl-2-carbethoxypyridine.