Xu Guangshan
2011
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Journal
Chinese Journal of Pharmaceuticals
Abstract
4-Amino-2-chloro-6,7-dimethoxyquinazoline,a key intermediate of quinazoline drugs such as terazosin,was synthesized from vanillin by methylation,nitration,oxidation,esterification,reduction,cyclization, chlorination and animation.The effects of reaction temperature and mole ratio of the reactants were investigated in the nitration and oxidation.The overall yield of the target compound was about 37%after improvement of the process.