Defeng Xu, Xing Xu, Zhiling Zhu
Oct 1, 2013
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Influential Citations
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Journal
Journal of Chemical Research
Abstract
A convenient and concise synthesis of 2-Fluoro-4-nitrobenzoic acid was obtained by oxidation of 2-fluoro-4-nitrotoluene with potassium permanganate in the presence of a phase transfer catalyst in 74% yield. N-methyl-2-fluoro-4-nitrobenzamide was then produced via chlorination and amination in 95% yield. Hydrogenation in the presence of Pd/C can afforded 4-amino-2-fluoro-N-methyl-benzamide in 98% yield