Assunta Giordano, A. Spinella, G. Sodano
May 21, 1999
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0
Influential Citations
12
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Journal
Tetrahedron-asymmetry
Abstract
Abstract Four diastereomers of 4-amino-3-hydroxy-2-methylpentanoic acid, an amino acid constituent of the hexapeptide portion of the antitumor antibiotic bleomycin A 2 , have been stereoselectively synthesized by crotylboration of N -Boc- l -alaninal. The synthesis allowed the assignment of the stereochemistry as 2 R ,3 S ,4 S to the 4-amino-3-hydroxy-2-methylpentanoic acid occurring in the tripeptide marine toxin janolusimide.