Feng Bai-cheng
2009
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0
Influential Citations
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Journal
Journal of Qingdao University of Science and Technology
Abstract
4-Amino-N-[3-(2-hydroxyethyl)sulfonylsulfatide]phenylbenzamide was synthesized using 4-nitro-N-[3-(2-hydroxyethyl)sulfonyl]phenylbenzamide and chlorosulfonic acid as starting materials through hydrogenation and esterification.The obtained optimum conditions for hydrogenation were using methanol as solvent,Raney-Ni as catalyst,temperature 60 ℃,pressure 0.4~0.6 MPa,reaction time 80 min.Under above conditions,the yield was 86%.The obtained optimum conditions for esterification were n(4-amino-N-[3-(2-hydroxyethyl)sulfonyl] phenylbenzamide):n(chlorosulfonic acid)=1∶1.05,temperature 40 ℃,reaction time 8 h.Under above conditions,the yield was 92 %.The obtained product and intermediate were characterized by IR and 1H NMR.