R. Kaur, Monika Bansal, B. Kaur
Jul 30, 2011
Citations
0
Influential Citations
7
Citations
Journal
Journal of Chemical Sciences
Abstract
Abstract.A simple and efficient method has been developed for the synthesis of series of 4-aryl-1,3,4,5-tetrahydro-2H-indeno[1,2-d]pyrimidine-2-thiones through Biginelli’s one-pot multicomponent condensation reaction via microwave irradiations. Then, these thiones were converted to their S-alkylated/aralkylated derivatives. The prepared heterocyclic products were structurally confirmed by analytical and spectral data and evaluated for their antibacterial activities. The results showed that this skeletal framework exhibited marked potency as antibacterial agents. The compound 2-(Ethylthio)-4-(4-Hydroxy-3-methoxyphenyl)-4,5-dihydro-1H-indeno[1,2-d]pyrimidines 4b have shown antibacterial activity towards all the seven clinical isolates used. Graphical AbstractThe synthesis and antibacterial activities of several indeno[1,2-d]pyrimidine-2-thione derivatives are described.