E. Corley, K. Conrad, J. Murry
Jun 25, 2004
Citations
0
Influential Citations
40
Citations
Journal
The Journal of organic chemistry
Abstract
A general procedure for the synthesis of 4-arylpiperidines via the coupling of 4-(N-BOC-piperidyl)zinc iodide with aryl halides and triflates is presented. The reaction requires cocatalysis with both Cl(2)Pd(dppf) and a copper(I) species. An improved, safer procedure for the activation of zinc dust is also presented.