Li Yong-qiang
2012
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Journal
Journal of Qingdao University of Science and Technology
Abstract
4-Bromo-2-fluorobiphenyl was synthesized by one pot method using 4-bromo2-fluoroaniline bromate as starting material through diazotization and coupling reaction.The effects of various condition parameters on reaction results were examined.The optimum reaction conditions were n(4-bromo-2-fluoroaniline bromate) ∶n(sodium nitrite) ∶ n(composite acid) ∶n(cuprous chloride) =1∶1.180∶1.36∶0.059,reaction temperature 40℃,and reaction time being 16h.Under above conditions,the yield of product was 63.85%.The cost of acidic reagent could be reduced as much as 95%by using composite acid instead of trichloroacetic acid,although the yield of product was slightly decreased.