Zhang Xing-chen
2008
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Journal
Journal of Hebei Normal University
Abstract
In presence of pyridine,4-bromo-N,N-dimethylaniline was synthesized by substitution reaction starting from N,N-dimethylaniline and bromine.In this reaction,the easy handle together with bigger volume brominating agent pyridinium tribromide was produced and the selectivity of 4-substitution reaction was enhanced.The optimal molar ratio was n(C8H11N)∶n(Br2)∶n(C5H5N) =1∶1.1∶1.1,the reaction was at 10~15 ℃ for 6 h to give the product in 68 % yield.Moreover the products were also obtained in middle yield in presence of some inorganic base.