Li De-liang
2010
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Journal
Applied Chemical Industry
Abstract
2-Chloro-1-(4-chlorophenyl) ethanone was synthesized from chlorobenzene and chloroacetyl chloride under the catalysis of aluminum chloride for 3~4 h with a yield of 87%,the mass ratio of aluminum chloride to chloroacetyl chloride was 1.3∶1.Then 4'-chloro-2-(1H-1,2,4-triazol-1-yl) acetophenone was prepared from it together with 1,2,4-triazole under the phase transfer catalysis of tetrabutyl ammonium bromide(3% of 1,2,4-triazole by molar ratio) for 4~5 h.The yield of 4'-chloro-2-(1H-1,2,4-triazol-1-yl) acetophenone was up to 68%.All the reactions were carried out at 45 ℃.