Zhao Hao-yu
2011
Citations
0
Influential Citations
2
Citations
Journal
Chemistry World
Abstract
A synthesis method of 4-chloro-2,5-difluorobenzoic acid from 2,5-difluoroaniline by Sandmeyer reaction,bromination and Grignard reaction was proposed.The optimal reaction conditions of bromination were: n(2-chloro-1,4-difluorobenzene)∶n(Br_2)=1∶1.13,n(2-chloro-1,4-difluorobenzene)∶n(FeCl_3)=1∶0.03,bromination temperature=30 ℃,and bromination time=5 h.The overall yield was 31%,and the purity of product was 99.16%(HPLC).The structure of the product was confirmed by MS and ~1H NMR.