Sha Yao-wu
2008
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Journal
Chemical Research and Application
Abstract
The novel compounds 7-Methoxy-4-oxo-6-pivalamide-1,4-dihydroquinazoline(10)and 4-chloro-7-methoxy-6-pivalamidoquinazoline(11)are synthesized in ten steps from 4-methoxybenzoic acid.During the synthesis,protective and deprotective methods are employed in the nitration and reduction steps.This new functionalized quinazoline entity can be modified with other active moieties,which may have special antitumor activities.