Li De-chen
2005
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Journal
West China Journal of Pharmaceutical Sciences
Abstract
OBJECTIVE To synthesize 4-chlorobutanal acetal by improved method. METHODS The title compound was prepared from (γ-butyrolactone) by ring-opening reaction, halogenation, catalytic hydrogenation and acetalization. RESULTS Chemical structures of the product were confirmed by ()~1HNMR. The total yield of product was 46.6%. CONCLUSION This synthetic technique features accessible starting materials, convenient performance and easy commercial production.