Li Meiling
2010
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Journal
Journal of Zhengzhou University
Abstract
Aim:To study the synthetic process for 4'-Cl-4"-benzyloxy-phenylbutazone.Methods:4'-Cl-4"-benzyloxy-phenylbutazone was synthesized by 4'-Cl-phenylamine through four-step reaction of diazotization coupling,benzylation,zinc powder reduction,and cyclization.Results:The structure of 4'-Cl-4"-benzyloxy-phenylbutazone compoud was verified by IR,NMR and MS.The overall yield was 29.6%.Conclusion:The process is simple and the reaction is mild.