J. Caldwell, K. Cheung, I. Collins
Feb 26, 2007
Citations
0
Influential Citations
13
Citations
Journal
Tetrahedron Letters
Abstract
Synthesis of 4-(cyclic dialkylamino)-7-azaindoles by microwave heating of 4-halo-7-azaindoles and cyclic secondary amines Nucleophilic aromatic substitution of 4-chloro- and 4-fluoro-7-azaindoles with cyclic secondary amines tinder microwave heating gave a straightforward and rapid synthesis of 4-(cyclic dialkylamino)-7-azaindoles. 4-Fluoro-7-azaindoles showed a greater reactivity towards SNAr reactions tinder these conditions than 4-chloro-7-azaindole.