Viktoriya А. Proshchenkova, V. Shuvalov, Larisa V. Glyzdinskaya
Feb 1, 2021
Citations
0
Influential Citations
1
Citations
Journal
Chemistry of Heterocyclic Compounds
Abstract
4-Ethoxycarbonyl(cyano)-1,3-dimethyl-β-carbolines were synthesized via thermolysis of 4-aryl-3(5)-azidopyridines and their optical and hypoglycemic properties were studied. For the first time, the accessible Hantzsch nitropyridines were used as the starting materials. Diazotization of 3-aminopyridines having a trimethoxyaryl substituent at the C-4 position of the pyridine ring by intramolecular azo coupling afforded 7,8,9-trimethoxy-2,4-dimethylpyrido[3,4- c ]cinnolines. When evaluating the hypoglycemic properties of the four obtained β-carbolines, it was found that ethyl 7-fluoro-1,3-dimethyl-9 H -pyrido[3,4- b ]indole-4-carboxylate, the structure of which contains the fluorine atom, has the highest glucose-lowering action.